Projekt

Daten zum Projekt

Cutaneous Leishmaniasis in northern Cameroon: immunological studies of Leishmania and Leishmania/HIV co-infection in the Mokolo endemic focus

Initiative: Wissen für morgen – Kooperative Forschungsvorhaben im subsaharischen Afrika
Ausschreibung: Tropical Medicine 2004
Bewilligung: 11.07.2006
Laufzeit: 3 Jahre

Projektinformationen

Cutaneous leishmaniasis (CL) is a protozoan parasitic disease with 1-1.5 millions new cases per year worldwide and is widely regarded to be one of the most important opportunistic infections in HIV+ individuals. Recently, studies of CL in murine and other systems have identified several important mechanisms of host immune responses raised against Leishmania major. However, the relevance of these important findings for humans remains to be shown. The project aims at defining aspects of the immune response against L. major in CL patients and in patients co-infected with L. major and HIV, including an evaluation of the prevalence of CL and Leishmania/HIV co-infection in an endemic focus of CL (northern Cameroon), the identification of underlying cellular and humoral mechanisms of susceptibility and resistance in L. major-infected patients and a correlation of the clinical course of CL with the host immune response in affected patients. In addition to the scientific work, the medical personnel will be trained in the diagnosis, management and report of CL cases. The project could lead to the identification of novel mechanisms of protection against Leishmania and in the long run to the development of improved treatment concepts, the generation of effective vaccine strategies and the design of an effective control program.

Projektbeteiligte

  • Prof. Dr. Esther von Stebut-Borschitz

    Universitätsmedizin der Johannes
    Gutenberg-Universität Mainz
    Hautklinik und Poliklinik
    Mainz

  • Dr. Blaise Dondji

    University of Ngaoundére
    Faculty of Natural Sciences
    Department of Biological Sciences
    Ngaoundéré
    Kamerun (Cameroun)

  • Prof. Dr. Marcus Maurer

    Charité - Universitätsmedizin Berlin
    Klinik für Dermatologie, Venerologie
    und Allergologie
    Berlin

  • Prof. Dr. Albert-Legrand Same-Ekobo

    University of Yaoundé
    Faculty of Medicine and Biomedical Sciences
    Medical Division
    Laboratory of Parasitology & Mycology
    Yaoundé
    Kamerun (Cameroun)