Projekt

The aim of this project is to create bioactive peptide nanofibrils (PNFs) that enhance retroviral gene transfer in vitro, ex vivo and in vivo in a safe and cell-type specific fashion, which will be exemplified for treatment of the genetic disease hemophilia B. Functionalized PNFs will be developed that enhance in vitro, ex vivo and in vivo gene delivery in a cell-type specific fashion. The safety and efficacy of our approach will be verified in a mouse model of hemophilia B. Functionalizaton with hepatocyte-targeting peptides, introduction of break points into the peptide sequence and imaging groups will be crucial to achieve cell-type or organ-specific gene transfer and to control the stability and distribution of PNFs in vivo. The realization of the approach would represent a breakthrough in biomedical research and opens exciting future prospects for the treatment of various diseases.

• Prof. Dr. Tanja Weil

  Max-Planck-Institut für Polymerforschung
  Mainz
  Department Synthese von Makromolekülen
  Mainz
  

• Prof. Dr. Frank Kirchhoff

  Universitätsklinikum Ulm
  Medizinische Fakultät
  Institut für Molekulare Virologie
  Ulm
  

• Prof. Dr. Jan Münch

  Universitätsklinikum Ulm
  Medizin
  Institut für Molekulare Virologie
  Ulm
  

• Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels

• Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

• Autonomous Ultrafast Self Healing Hydrogels by pH Responsive Functional Nanofiber Gelators as Cell Matrices

• Sequence-Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons

• Structure, function and antagonism of semen amyloids