Projekt

It is planned to use a novel approach to investigate the molecular mechanisms promoting hereditary and toxicity-induced neurodegeneration. Identification of the key factors (e.g. novel SWS interactors or certain miRNAs) that control SWS function upon aging and stress will provide valuable new insights into the mechanisms mediating neuropathy and will facilitate the discovery of novel drug targets to combat age-related neurodegeneration. Presently, the amount of data on the role for miRNAs in neurodegenerative disorders is scarce, while their potential as new therapeutic agents and novel drug targets is tremendous. Thus, this project will provide new directions for therapeutic intervention and will specifically suggest the use of neroprotective miRNAs as new attractive approaches to modulate the activity of critical enzymes during aging or under stress conditions.

• Priv.-Doz. Dr. Halyna Shcherbata

  Max-Planck-Institut für
  biophysikalische Chemie
  Genexpression und Signalwirkung
  Göttingen
  

• Dr. Svetlana Sarantseva

  National Research Center
  Kurchatov Institute
  Molecular and Radiation Biophysics Division
  Gatchina, Leningrad district
  Russland
  

• Dr. Nataliya Matiytsiv

  Ivan Franko National University of Lviv
  Department of Genetics and Biotechnology
  Lviv
  Ukraine