Daten zum Projekt
Initiative: | Trilaterale Partnerschaften – Kooperationsvorhaben zwischen Wissenschaftler(inne)n aus der Ukraine, Russland und Deutschland |
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Bewilligung: | 15.02.2016 |
Laufzeit: | 2 Jahre |
Projektinformationen
The project aims to discover new drug targets for co-morbid diseases in humans using such frequently co-morbid pathologies as asthma and hypertension. A computer search will be carried out to fulfil the target. For genes for potential drug targets identified insilico, the probability of the effect of promoter single nucleotide polymorphisms (SNPs) on the efficiency of transcription factor binding will be estimated. The SNPs with highest possible functional effect will be further explored for their association with asthma, hypertension, and a combination of the diseases. To identify pathogenetic significance of regulatory variants of the studied genes, an assessment of their impact on the level of expression of different categories of patients will be carried out. A rodent model of asthma and hypertension co-morbidity will be established and the common genes for asthma and hypertension will be investigated to reveal their pathophysiological impact on the development of the diseases. RNA-interference and other approaches will be used to reveal potential therapeutic relevance of common genes. Overall, the study will examine molecular features of common co-morbidity of asthma and hypertension and will also identify potential drug targets for the treatment of these conditions.
Projektbeteiligte
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Prof. Dr. Ralf Hofestädt
Universität Bielefeld
Technische Fakultät
AG Bioinformatik und Medizinische Informatik
Bielefeld
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Dr. Elena Bragina
Research Institute for Medical Genetics
Tomsk
Russland
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Prof. Victor Dosenko
National Academy of Sciences of Ukraine
Bogomoletz Institute of Physiology
Kiev
Ukraine
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Dr. Vladimir Ivanisenko
Russian Academy of Sciences
Siberian Branch
Institute of Cytology and Genetics
Novosibirsk
Russland