Projekt

Daten zum Projekt

In silico screening and experimental validation of new drug targets for the treatment of co-morbid multifactorial diseases.

Zur Projekt-Website

Initiative: Trilaterale Partnerschaften – Kooperationsvorhaben zwischen Wissenschaftler(inne)n aus der Ukraine, Russland und Deutschland
Bewilligung: 15.02.2016
Laufzeit: 2 Jahre

Projektinformationen

The project aims to discover new drug targets for co-morbid diseases in humans using such frequently co-morbid pathologies as asthma and hypertension. A computer search will be carried out to fulfil the target. For genes for potential drug targets identified insilico, the probability of the effect of promoter single nucleotide polymorphisms (SNPs) on the efficiency of transcription factor binding will be estimated. The SNPs with highest possible functional effect will be further explored for their association with asthma, hypertension, and a combination of the diseases. To identify pathogenetic significance of regulatory variants of the studied genes, an assessment of their impact on the level of expression of different categories of patients will be carried out. A rodent model of asthma and hypertension co-morbidity will be established and the common genes for asthma and hypertension will be investigated to reveal their pathophysiological impact on the development of the diseases. RNA-interference and other approaches will be used to reveal potential therapeutic relevance of common genes. Overall, the study will examine molecular features of common co-morbidity of asthma and hypertension and will also identify potential drug targets for the treatment of these conditions.

Projektbeteiligte

  • Prof. Dr. Ralf Hofestädt

    Universität Bielefeld
    Technische Fakultät
    AG Bioinformatik und Medizinische Informatik
    Bielefeld

  • Dr. Elena Bragina

    Research Institute for Medical Genetics
    Tomsk
    Russland

  • Prof. Victor Dosenko

    National Academy of Sciences of Ukraine
    Bogomoletz Institute of Physiology
    Kiev
    Ukraine

  • Dr. Vladimir Ivanisenko

    Russian Academy of Sciences
    Siberian Branch
    Institute of Cytology and Genetics
    Novosibirsk
    Russland

Open Access-Publikationen