Projekt

The current project aims to clarify the relation between glycosylation of cells, immunoglobulins and their effect on the immune response. The mechanism leading to the alteration of immunoglobulin glycosylation and pathogenicity of autoantibodies, abzymes and natural antibodies will be studied. The effect of impaired clearance of dying cells and formation of neutrophil extracellular traps on modification of glycan components and their contribution to the development of pro-inflammatory antibodies and immune complexes will be investigated. The specific input of these processes in development of pathological manifestations in several autoimmune diseases and autoimmune neuropathologies will be addressed. Realization of the project will allow to validate the developed lectin-ELISA test and introduce it for clinical practice for early detection of autoimmune disorders, to find specific ways to prevent accumulation of nuclear antigens in autoimmune disorders and damaging circulating pro-inflammatory antibodies. As a result diagnostic and treatment strategies for autoimmune disorders could lead an advantage and improvement in auto-immune and immune diseases, cancer research, transplantation technologies and infectious diseases.

• Prof. Dr. Martin Herrmann

  Universitätsklinikum Erlangen
  Medizinische Klinik 3
  Immunologie und Rheumatologie
  Erlangen
  

• Prof. Dr. Hans-Joachim Anders

  Klinikum der Universität München
  Nephrologisches Zentrum
  Medizinische Klinik und Poliklinik IV
  München
  

• Prof. Dr. Alexander Gabibov

  Russian Academy of Sciences
  Shemyakin-Ovchinikov Institute of Bioorganic
  Chemistry
  IBCh RAS, build. 31, office 600
  Moscow
  Russland
  

• Dr. Rostyslav Bilyy

  National Academy of Sciences of Ukraine
  Institute of Cell Biology
  Lviv
  Ukraine