Projekt

The main objective of this proposal is to realize a bottom-up strategy for tailored artificial tissue - a living foam - using multifunctional minimal cell compartments (MCCs) based on giant liposomes or polymersomes as fundamental building blocks. The living foam is characterized by dedicated molecular contacts between the compartments serving as cell-cell contact mimics comprising artificial gap junctions and artificial adherens junctions. The junctions permit to generate an interconnected communication network of MCCs that relay chemical and mechanical signals. Eventually, this design scheme will allow us to form actively driven foams in 3-D that resemble tissues in various ways. The foam will also allow replacing a fraction of living cells in native tissue to form hybrid structures either to substitute or to supply new properties paving the way towards a revolution in tissue engineering in the context of wound healing, contractile tissue, skin ageing and relaying signals for unperturbed bone development.

• Prof. Dr. Andreas Janshoff

  Universität Göttingen
  Fakultät für Chemie
  Institut für Physikalische Chemie
  Biophysikalische Chemie
  Göttingen
  

• Prof. Dr. Joachim Spatz

  Max-Planck-Institut für medizinische
  Forschung
  Dept. of Biointerphase
  Science & Technology
  Heidelberg
  

• Dr. Marco Tarantola

  Max-Planck-Institut für Dynamik und
  Selbstorganisation
  LFPB/Biophysics Group
  Göttingen
  

• Prof. Dr. Claudia Steinem

  Universität Göttingen
  Faculty of Chemistry
  Insitute of Organic and Biomolecular Chemistry
  Göttingen
  

• Prof. Dr. Eberhard Bodenschatz

  Max-Planck-Institut für Dynamik und
  Selbstorganisation
  Abteilung Hydrodynamik, Strukturbildung und
  Biokomplexität
  Göttingen
  

• HAV-Peptides Attached to Colloidal Probes Faithfully Detect E-Cadherins Displayed on Living Cells.

• pH-Triggered Assembly of Endomembrane Multicompartments in Synthetic Cells

• Flagellum-Driven Cargoes: Influence of Cargo Size and the Flagellum-Cargo Attachment Geometry