Projekt

Daten zum Projekt

Release of Nucleotides from Aminoacidyl Phosphoramidates of Nucleosides (additional Corona-related funding)

Initiative: "Leben?" - Ein neuer Blick der Naturwissenschaften auf die grundlegenden Prinzipien des Lebens (beendet)
Bewilligung: 27.10.2020
Laufzeit: 1 Jahr 6 Monate

Projektinformationen

Viral replication can be suppressed by releasing inhibitory nucleotides in infected cells. In a previous study, the team discovered an unexpected, rapid release pathway for aminoacidyl nucleotides. Now, the researchers propose the preparation and structural evaluation of phosphoramidates to understand this pathway and to gain insights that can aid to design better viral inhibitors.

Projektbeteiligte

  • Prof. Dr. Clemens Richert

    Universität Stuttgart
    Fakultät Chemie
    Institut für Organische Chemie
    Lehrstuhl Biologische Chemie
    Stuttgart

  • Prof. Dr. Martin Egli

    Vanderbilt University
    School of Medicine, Department of Biochemistry
    Nashville
    USA