Projekt

An interdependency of genetic information storage and propagation (heredity) and chemical energy dissipation (metabolism) is a hallmark of life. However, how coupling between metabolic and informational systems emerged and sustained has never been explored experimentally in a cross-disciplinary context. Experts in both experimental and theoretical aspects of systems chemistry and synthetic biology will explore these crucial aspects of the emergence of life through synthetic model systems by addressing the following questions: a) How can heredity arise from pools of information encoding polymers? b) How can heredity be coupled to energy dissipation through chemical cycles? c) How can physicochemical transitions such as liquid-liquid demixing drive such cycles? d) How can a coupled metabolic-genetic system sustain itself?

• Prof. Dr. Job Boekhoven, Ph.D.

  Technische Universität München
  Fakultät für Chemie
  Institute for Advanced Studies
  Garching
  

• Dr. Philipp Holliger, Ph.D.

  MRC Laboratory of Molecular Biology
  Protein & Nucleic Acid Chemistry
  Cambridge
  Grossbritannien
  

• Prof. Dr. Ulrich Gerland

  Technische Universität München
  Physik-Department
  Garching
  

• Fuel-Driven Dynamic Combinatorial Libraries