Projekt

The current project is aimed to clarify the role of NET-borne enzymes and proteins such as proteases, glycosidases and proteasomal subunits on the anti-inflammatory properties of NETs and their role in antigen presentation. The project partners will study in detail the presence and composition of functionally active proteasomes in neutrophils and associated with NETs. How other enzymes associated with NETs, such as PADI4, proteases and glycosidases are contributing to the anti-inflammatory properties of NETs will also be part of the current research project. Lastly, the consortium wants to better understand the impact of blocking Cat-S on PAR2 activation and as possible treatment options for MHC-driven allo-/autoimmunity and peripheral vascular organ damage.

• Prof. Dr. Martin Herrmann

  Universitätsklinikum Erlangen
  Medizinische Klinik 3
  Immunologie und Rheumatologie
  Erlangen
  

• Prof. Dr. Alexander Gabibov

  Russian Academy of Sciences
  Shemyakin-Ovchinikov Institute of Bioorganic
  Chemistry
  IBCh RAS, build. 31, office 600
  Moscow
  Russland
  

• Prof. Dr. Hans-Joachim Anders

  Klinikum der Universität München
  Nephrologisches Zentrum
  Medizinische Klinik und Poliklinik IV
  München
  

• Prof. Alexey Belogurov

  Russian Academy of Sciences
  Shemyakin-Ovchinnikov Institute of
  Bioorganic Chemistry
  Moskow
  Russland
  

• Prof. Dr. Rostyslav Bilyy

  Danylo Halytsky Lviv National Medical
  University
  Department of Cytology, Histology and Embryology
  Lviv
  Ukraine