Projekt

Daten zum Projekt

A plasmid goes viral: Understanding the origin and evolution of viruses by studying a newly discovered virus-like element.

Initiative: "Leben?" - Ein neuer Blick der Naturwissenschaften auf die grundlegenden Prinzipien des Lebens (beendet)
Bewilligung: 07.07.2020
Laufzeit: 3 Jahre

Projektinformationen

Extrachromosomal elements, such as plasmids or viruses, are ubiquitous in all three domains of life (eukaryotes, bacteria, archaea). Plasmids and viruses can both be considered as selfish genetic elements. However, plasmids can be distinguished from viruses by their lack of genetic information encoding structural proteins that allow cell exit and dissemination in capsids. Recently, the research team discovered the plasmid pR1SE, a novel extrachromosomal element from a hypersaline Antarctic lake exhibiting genomic characteristics of a plasmid, yet which is released from cells like a lipid-enveloped virus by forming membrane-containing capsid-like entities encasing the plasmid and structural proteins. This is the first time this mode of plasmid transfer, relying on so-called plasmid vesicles or plasmidions, has been reported. Plasmidions may represent evolutionary precursors of modern viruses and could thus offer the first direct evidence for the "escape hypothesis" of viral evolution amenable to laboratory investigation. Accordingly, an international team skilled in virology, microbiology, cell biology, genetics, structural biology, and biochemistry will characterize this unique element, comparing observed characteristics with those of lipid-enveloped viruses, thereby addressing the evolutionary relationship of plasmidions to viruses. The proposed research should provide fundamental advances in understanding the origin and evolution of viruses and related extrachromosomal elements, as well as their mechanisms of infection and transmission.

Projektbeteiligte

  • Dr. Susanne Erdmann, Ph.D.

    Max-Planck-Institut für marine
    Mikrobiologie
    Archaea Virologie
    Administrating Institution: MPG. Munich
    Bremen

  • Prof. Dr. Nicole Tischler

    Fundación Ciencia & Vida
    Laboratorio de Virologia Molecular
    Santiago
    Chile

  • Dr. Elina Roine

    University of Helsinki
    Faculty of Biological and Environmental Sciences
    Molecular and Integrative Biosciences Research Pro
    Helsinki
    Finnland

  • Prof. Jerry Eichler, Ph.D.

    Ben-Gurion University of the Negev
    Life Sciences
    Beersheva
    Israel

  • Prof. Juha Huiskonen, Ph.D.

    University of Helsinki
    Laboratory of Structural Biology
    Helsinki Institute of Life Science
    Helsinki
    Finnland