Daten zum Projekt

Biomimetic assembly of a photocatalytic unit for hydrogen production (extension)

Zur Projekt-Website

Initiative: Integration molekularer Komponenten in funktionale makroskopische Systeme (beendet, nur noch Fortsetzungsanträge)
Bewilligung: 03.12.2013
Laufzeit: 3 Jahre


The present proposal aims at designing of novel molecular devices for the light-driven production of hydrogen gas. The described strategies are based on two innovative approaches that have recently been established in the Happe group. The first procedure is based on the successful electrochemical linkage of two redox proteins via a dithiole linker compound. The second advance enables the spontaneous in vitro activation of [FeFe]-hydrogenases by adding an inorganic iron-sulfur mimic (2FeH) to the inactive precursor protein. Both methods will be employed to achieve the following objectives in the field of light-induced hydrogen production: a) Wiring metal free artificial photosensitizer molecules to a semi-artificial hydrogenase. b) Remodeling the natural FA/FB-cluster assembly of a bacterial ferredoxin and the photosystem I unit PsaC to incorporate and functionalize the 2FeH mimic compound for yielding new types of H2 evolving catalysts. On the basis of this innovative interdisciplinary approach one can expect to establish a platform on which synthetic protein environments can be developed and studied, allowing a collaboration of biologists and chemists with the aim of developing truly artificial H2-generating units.


  • Prof. Dr. Thomas Happe

    Universität Bochum
    Fakultät für Biologie und Biotechnologie
    Lehrstuhl Biochemie der Pflanzen
    AG Photobiotechnologie

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