Daten zum Projekt
| Initiative: | Trilaterale Partnerschaften – Kooperationsvorhaben zwischen Wissenschaftler(inne)n aus der Ukraine, Russland und Deutschland |
|---|---|
| Bewilligung: | 15.02.2016 |
| Laufzeit: | 3 Jahre |
Projektinformationen
Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be adressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-mimetics for future therapies. This project is expected to produce fundamental knowledge on the effects of ageing on neurons, astrocytes and microglia both in vitro and in vivo and on the mechanisms underlying caloric restriction-based improvement of their function. Based on the data obtained one shall be able to identify critical cellular/molecular pathways that can be targeted by CR-mimetics for future therapies.
Projektbeteiligte
-
Prof. Dr. Olga Garaschuk
Universitätsklinikum Tübingen
Medizinische Fakultät
Physiologisches Institut
Lehrstuhl für Neurophysiologie
Tübingen
-
Prof. Dr. Volodymyr Lushchak
Vasyl Stefanyk Precarpathian
National University
Department of Biochemistry and Biotechnology
Ivano-Frankivsk
Ukraine
-
Prof. Dr. Alexei Verkhratsky
Staatliche Universität Nizhny Novgorod
Laboratory of Neuronal-glial interactions
in health and disease
Nizhny Novgorod
Russland
-
Prof. Dr. Alexey Semyanov
Staatliche Universität Nizhny Novgorod
Institute of Biology and Biomedicine
Nizhny Novgorod
Russland