Daten zum Projekt

Cellular mechanisms of healthy brain ageing under caloric restriction

Initiative: Trilaterale Partnerschaften – Kooperationsvorhaben zwischen Wissenschaftler(inne)n aus der Ukraine, Russland und Deutschland
Bewilligung: 15.02.2016
Laufzeit: 3 Jahre


Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be adressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-mimetics for future therapies. This project is expected to produce fundamental knowledge on the effects of ageing on neurons, astrocytes and microglia both in vitro and in vivo and on the mechanisms underlying caloric restriction-based improvement of their function. Based on the data obtained one shall be able to identify critical cellular/molecular pathways that can be targeted by CR-mimetics for future therapies.


  • Prof. Dr. Olga Garaschuk

    Universitätsklinikum Tübingen
    Medizinische Fakultät
    Physiologisches Institut
    Lehrstuhl für Neurophysiologie

  • Prof. Dr. Volodymyr Lushchak

    Vasyl Stefanyk Precarpathian
    National University
    Department of Biochemistry and Biotechnology

  • Prof. Dr. Alexei Verkhratsky

    Staatliche Universität Nizhny Novgorod
    Laboratory of Neuronal-glial interactions
    in health and disease
    Nizhny Novgorod

  • Prof. Dr. Alexey Semyanov

    Staatliche Universität Nizhny Novgorod
    Institute of Biology and Biomedicine
    Nizhny Novgorod

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