Projekt

Daten zum Projekt

Microbial and environmental factors that control gut-resident memory T cells in human health and disease: molecular signatures, function, and interaction partners

Initiative: Lichtenberg - Professuren
Bewilligung: 01.06.2018
Laufzeit: 5 Jahre

Projektinformationen

The human intestine harbours a vast and diverse bacterial community that exerts several beneficial effects on the host such as a profound effect on immune responses. Maladaptation of this host-microbe dialogue can promote inflammatory responses and is implicated in various pathologies including inflammatory bowel disease (IBD). However, the microbial signals and molecular pathways that promote tissue-specific differentiation of gut-resident immune cells are still poorly characterized. Using cutting-edge technologies, a multidisciplinary approach, well-defined patient cohorts, and mouse models of colitis, this project aims at deciphering the complex host-microbiota relationship, i.e. the interactions between microbial, environmental, and inflammatory factors that promote intestinal inflammation. The overall goal is to utilize the acquired knowledge to identify targetable cytokine signals and pathogenic molecular pathways in microbiota-specific CD4+ T cell populations for therapeutic development in IBD.

Projektbeteiligte

  • Prof. Dr. Dr. Ahmed N. Hegazy

    Charité - Universitätsmedizin Berlin
    Medizinische Klinik für Gastroenterologie,
    Infektiologie und Rheumatologie
    Campus Benjamin Franklin
    Berlin

Open Access-Publikationen