Projekt

The Respiratory Syncytial Virus (RSV) is the most frequent cause of lower respiratory tract infections among infants. The course and outcome of primary RSV infection are highly variable and the factors controlling severe disease poorly defined. A prophylactic antibody is used to protect infants at very high risk (e.g. due to pre-term birth). However, incomplete knowledge of RSV infection risk factors prevents protection of all children in need. The objective of INDIRA is to discover biomarkers predictive of severe RSV disease and to understand how these control disease severity.INDIRA integrates comprehensive biological and clinical datasets from patients with severe primary RSV infection. Using computational methods including machine learning intelligence, individual markers and marker combinations are associated with severe disease and validated in functional virological and immunological experiments. INDIRA aims to break ground in the understanding of determinants of severe RSV infection of infants for development of molecular diagnostics that ultimately will allow personalized phrophylaxis for the most vulnerable infants.

• Prof. Dr. Thomas Pietschmann

  Medizinische Hochschule Hannover
  TWINCORE - Zentrum für experimentelle und
  klinische Infektionsforschung
  Experimentelle Virologie
  Hannover
  

• Prof. Dr. Thomas Illig

  Medizinische Hochschule Hannover
  Institut für Humangenetik
  Hannover
  

• Prof. Dr. Lars Kaderali

  Universitätsmedizin Greifswald
  Greifswald
  

• Prof. Dr.-Ing. Jörn Ostermann

  Universität Hannover
  FB Elektrotechnik und Informatik
  Institut für Informationsverarbeitung
  Hannover
  

• Prof. Dr.-Ing. Bodo Rosenhahn

  Universität Hannover
  Fachbereich Elektrotechnik und Informatik
  Automatische Bildinterpretation
  Hannover
  

• Dr. Robert Geffers

  Helmholtz-Zentrum für
  Infektionsforschung GmbH
  FB Molekulare Bakteriologie
  Arbeitsgruppe Genomanalytik
  Braunschweig
  

• Prof. Dr. Jörg Overmann

  Leibniz-Institut DSMZ -
  Deutsche Sammlung von Mikroorganismen
  und Zellkulturen GmbH
  Braunschweig
  

• Prof. Dr. Gesine Hansen

  Medizinische Hochschule Hannover
  Zentrum Kinderheilkunde und Jugendmedizin
  Klinik für Pädiatrische Pneumologie,
  Allergologie und Neonatologie
  Hannover
  

• Prof. Dr. Karsten Hiller

  Technische Universität Braunschweig
  Abteilung für Biochemie und Bioinformatik
  BRICS
  Braunschweig