Projekt

Daten zum Projekt

Exploring advanced Raman microscopy as a tool to Localize and Quantify Metabolites in Neural tissue

Initiative: Kurswechsel – Forschungsneuland zwischen den Lebenswissenschaften und Natur- oder Technikwissenschaften
Ausschreibung: Planning Grants
Bewilligung: 11.01.2021
Laufzeit: 1 Jahr 6 Monate

Projektinformationen

The complex interplay of neurons and glia is vital for the functioning of the nervous system. In the brain, energy metabolism plays a major role in this relationship and in the recent years, metabolic supply of axons has emerged as a major function of glial cells. Currently it is unclear whether the Schwann cells of the peripheral nervous system play a similar role, which is of special importance in view of metabolic alterations in hereditary diseases. Thus, a versatile method is needed to identify small molecules like sugars in nerve tissue with sub-cellular resolution, but up to now there is no such technique available. Microscopic measurement of Raman scattering allows for label-free identification and quantification of a variety of molecules. Here, with the help of experts in Raman scattering, life scientists change their course towards establishing surface-enhanced Raman spectroscopy as a powerful method for sub-cellular analysis of small molecules in nervous tissue.

Projektbeteiligte

  • Prof. Dr. Michael Sereda

    Universitätsmedizin Göttingen
    Georg August Universität
    Klinik für Neurologie
    Göttingen

  • Dr. Hainer Wackerbarth

    Institut für Nanophotonik
    Göttingen e.V.
    Photonische Sensor Technologie
    Göttingen

  • Dr. David Ewers

    Universitätsmedizin Göttingen
    Georg August Universität
    Klinik für Neurologie
    Göttingen