Daten zum Projekt
| Initiative: | "Experiment!" (beendet) |
|---|---|
| Ausschreibung: | Explorative Phase |
| Bewilligung: | 02.03.2021 |
| Laufzeit: | 1 Jahr 6 Monate |
Projektinformationen
The hugely variable sugar composition of viral envelope proteins can interfere with antibody binding, however, can it also maintain a viral infection by creating a subpopulation of viral particles that are unrecognizable for the immune system? Using the human immunodeficiency virus (HIV), which is highly decorated with a dense coat of variable sugar types and a new flow cytometry method called flow virometry, this question will be investigated. If there is sugar diversity-based viral escape, the characterization of this new mechanism might broadly improve the success of future antibody-based biomedical interventions against viruses.
Projektbeteiligte
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Prof. Dr. Christina Karsten
Universitätsklinikum Essen
Institut für translationale HIV-Forschung
Essen